Most pain stops when the drug is discontinued, but don stop taking it without consulting your doctor first. All patients were supplemented with 1000 mg elemental calcium and 400 IU vitamin per actonel non prescrizione day. The drug binds to certain cells in bones and slows down the rate at which bone breaks down. Contact Our News Editors For any corrections of factual information, or to contact the editors please use our feedback form. In addition, serum bone-specific alkaline phosphatase was also reduced by 42 and 41 in the ACTONEL mg daily and ACTONEL 35 mg once-a-week groups, respectively.